DISSEMINATED INFECTION DUE TO FUSARIUM SP. IN A PATIENT WI TH CHRONIC GRANULOMATOUS DISEASE

The present report discusses disseminated fusariosis in a 15 year old boy with chronic granulomatous disease (CGD). He was admitted to the Hazrat Rasool Acram Hospital in November 1995, with a chronic wound in the right ankle and buttock area. Antibacterial therapy was started, but there was no response. The patient was still febrile. Chest x-ray revealed parahilar lesions in both lungs. Tissue biopsy and broncho-alveolar lavage were performed and the specimens were sent to Pasteur Institute. In both specimens, Fusarium sp. was recognized as the pathologic agent by direct smear and culture techniques. The patient underwent antifungal therapy receiving amphotericin B and oral ketoconazole. The result of this treatment suggests that aggressive management of fusariosis offers the best chance of survival. This paper reports the first case of disseminated fusariosis in Iran.